Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents

M Patel; J D Rodgers; R J McHugh Jr; B L Johnson; B C Cordova; R M Klabe; L T Bacheler; S Erickson-Viitanen; S S Ko

doi:10.1016/s0960-894x(99)00564-8

Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents

Bioorg Med Chem Lett. 1999 Nov 15;9(22):3217-20. doi: 10.1016/s0960-894x(99)00564-8.

Authors

M Patel¹, J D Rodgers, R J McHugh Jr, B L Johnson, B C Cordova, R M Klabe, L T Bacheler, S Erickson-Viitanen, S S Ko

Affiliation

¹ DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0500, USA.

PMID: 10576691
DOI: 10.1016/s0960-894x(99)00564-8

Abstract

The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to the lead compound of the series SE063.

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology
HIV Protease / drug effects
HIV Protease Inhibitors / chemistry*
HIV Protease Inhibitors / pharmacology
HIV-1 / enzymology
Urea / chemistry*
Urea / pharmacology

Substances

Anti-HIV Agents
HIV Protease Inhibitors
Urea
HIV Protease